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CYP2 family: drug metabolising subset C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CYP1, 2 and 3 family enzymes are involved in the biotransformation of xenobiotics, including clinically used drugs. Polymorphisms, particularly in the CYP2 family, impact upon an individual's response to drugs [30], including the risk of adverse drug reactions, drug efficacy and dose requirement.

Enzymes

1323
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CYP2A6 C Show summary » More detailed page go icon to follow link

CYP2A7 C Show summary »

CYP2A13 C Show summary »


Target Id 1323
Nomenclature CYP2A13
Previous and unofficial names cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 13 | cytochrome P450, family 2, subfamily A, polypeptide 13
Genes CYP2A13 (Hs)
Ensembl ID ENSG00000197838 (Hs)
UniProtKB AC Q16696 (Hs)
EC number
1.14.14.1
Inhibitors
kaempferol pKi 6.9 [4]
Comment Metabolises tobacco carcinogen, 4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone [23]. Expressed specifically in the respiratory tract.

CYP2B6 C Show summary » More detailed page go icon to follow link

CYP2C8 C Show summary » More detailed page go icon to follow link

CYP2C9 C Show summary » More detailed page go icon to follow link

CYP2C18 Show summary »

CYP2C19 C Show summary »

CYP2D6 C Show summary » More detailed page go icon to follow link

CYP2E1 C Show summary » More detailed page go icon to follow link

CYP2F1 C Show summary »

CYP2J2 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.