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CYP2 family: drug metabolising subset C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CYP1, 2 and 3 family enzymes are involved in the biotransformation of xenobiotics, including clinically used drugs. Polymorphisms, particularly in the CYP2 family, impact upon an individual's response to drugs [31], including the risk of adverse drug reactions, drug efficacy and dose requirement.

Enzymes

1332
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CYP2A6 C Show summary » More detailed page go icon to follow link

CYP2A7 C Show summary »

CYP2A13 C Show summary »

CYP2B6 C Show summary » More detailed page go icon to follow link

CYP2C8 C Show summary » More detailed page go icon to follow link

CYP2C9 C Show summary » More detailed page go icon to follow link

CYP2C18 Show summary »

CYP2C19 C Show summary »

CYP2D6 C Show summary » More detailed page go icon to follow link

CYP2E1 C Show summary » More detailed page go icon to follow link

CYP2F1 C Show summary »

CYP2J2 C Show summary »


Target Id 1332
Nomenclature CYP2J2
Previous and unofficial names cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2 | Arachidonic acid epoxygenase | cytochrome P450, family 2, subfamily J, polypeptide 2
Genes CYP2J2 (Hs)
Ensembl ID ENSG00000134716 (Hs)
UniProtKB AC P51589 (Hs)
EC number
1.14.14.1
Inhibitors
compound 4 [PMID: 16495056] pIC50 6.8 [15]
terfenadine pIC50 5.1 [15]
Comment Converts arachidonic acid to 14(R)-15(S)-epoxyeicosatrienoic acid [28]. Hydroxylates albendazole[29]. Expressed in cardiomyocytes [22].

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.