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tebapivat   Click here for help

GtoPdb Ligand ID: 13106

Synonyms: AG-946 | AG946 | compound 27 [PMID: 38109501]
PDB Ligand
Compound class: Synthetic organic
Comment: Tebapivat (AG-946) is a small molecule activator of pyruvate kinase (PK) [2]. It acts allosterically, at wild type PK and at physiologically relevent PK isoforms (e.g. PK-R that's expressed in red blood cells). It is intended to increase PK function in red blood cells with defective glycolysis, as observed in diseases such as myelodysplastic syndromes and sickle cell anaemia [3-4].

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 136.34
Molecular weight 392.44
XLogP 0.32
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN1C2=C(C=NN(CC3=CC=CC(=N3)N)C2=O)C4=C1N=C(CC5=NNC=C5)S4
Isomeric SMILES N1N=C(C=C1)CC=2SC3=C(N(C=4C(N(N=CC43)CC5=NC(=CC=C5)N)=O)C)N2
InChI InChI=1S/C18H16N8OS/c1-25-15-12(16-17(25)23-14(28-16)7-10-5-6-20-24-10)8-21-26(18(15)27)9-11-3-2-4-13(19)22-11/h2-6,8H,7,9H2,1H3,(H2,19,22)(H,20,24)
InChI Key DIUOELXIXSCFCR-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. FDA. 
Orphan Drug Designations and Approvals: tebapivat.
Accessed on 29/04/2026. Modified on 29/04/2026. www.accessdata.fda.gov, www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=1125325
2. Liu T, Padyana AK, Judd ET, Jin L, Hammoudeh D, Kung C, Dang L. (2024)
Structure-Based Design of AG-946, a Pyruvate Kinase Activator.
ChemMedChem, 19 (5): e202300559. [PMID:38109501]
3. Matte A, Federti E, De Franceschi L. (2023)
Erythrocyte pyruvate kinase activation in red cell disorders.
Curr Opin Hematol, 30 (3): 93-98. [PMID:36853806]
4. Xu JZ, Vercellotti GM. (2023)
Pyruvate kinase activators: targeting red cell metabolism in sickle cell disease.
Hematology Am Soc Hematol Educ Program, 2023 (1): 107-113. [PMID:38066891]