tebapivat   Click here for help

GtoPdb Ligand ID: 13106

Synonyms: AG-946 | AG946 | compound 27 [PMID: 38109501]
PDB Ligand
Compound class: Synthetic organic
Comment: Tebapivat (AG-946) is a small molecule activator of pyruvate kinase (PK) [1]. It acts allosterically, at wild type PK and at physiologically relevent PK isoforms (e.g. PKR that's expressed in red blood cells). It is intended to increase PK function in red blood cells with defective glycolysis, as observed in diseases such as myelodysplastic syndromes and sickle cell anaemia.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 136.34
Molecular weight 392.44
XLogP 0.32
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN1C2=C(C=NN(CC3=CC=CC(=N3)N)C2=O)C4=C1N=C(CC5=NNC=C5)S4
Isomeric SMILES N1N=C(C=C1)CC=2SC3=C(N(C=4C(N(N=CC43)CC5=NC(=CC=C5)N)=O)C)N2
InChI InChI=1S/C18H16N8OS/c1-25-15-12(16-17(25)23-14(28-16)7-10-5-6-20-24-10)8-21-26(18(15)27)9-11-3-2-4-13(19)22-11/h2-6,8H,7,9H2,1H3,(H2,19,22)(H,20,24)
InChI Key DIUOELXIXSCFCR-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
AG-946 was advanced to clinical trial as an investigational PK/PKR allosteric activator.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04536792 A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-946 in Healthy Volunteers and in Participants With Sickle Cell Disease Phase 1 Interventional Agios Pharmaceuticals, Inc.
NCT05490446 A Study of AG-946 in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS) Phase 2 Interventional Agios Pharmaceuticals, Inc.