Synonyms: AG-946 | AG946 | compound 27 [PMID: 38109501]
Compound class:
Synthetic organic
Comment: Tebapivat (AG-946) is a small molecule activator of pyruvate kinase (PK) [1]. It acts allosterically, at wild type PK and at physiologically relevent PK isoforms (e.g. PKR that's expressed in red blood cells). It is intended to increase PK function in red blood cells with defective glycolysis, as observed in diseases such as myelodysplastic syndromes and sickle cell anaemia.
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Bioactivity Comments |
Half maximal activation concentration (AC50) for wild type human PK is 5 nM [1]. |