SR1001

Ligand id: 10143

Name: SR1001

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 145.01
Molecular weight 477.03
XLogP 2.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Other than RORα and RORγ, SR1001 is devoid of activity at any of 48 tested nuclear receptors (including RORβ and LXRα) [2].
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
RAR-related orphan receptor-γ Hs Agonist Inverse agonist 6.9 pKi - 2
pKi 6.9 (Ki 1.11x10-7 M) [2]
Description: Competitive radioligand binding assay using [3H]25-hydroxycholesterol as tracer.
RAR-related orphan receptor-α Hs Agonist Inverse agonist 6.8 pKi - 2
pKi 6.8 (Ki 1.72x10-7 M) [2]
Description: Competitive radioligand binding assay using [3H]25-hydroxycholesterol as tracer.