Ligand id: 10143

Name: SR1001

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 145.01
Molecular weight 477.03
XLogP 2.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
SR1001 has high affinity for both RORα and RORγt. It suppresses Th17 cell differentiation and production of Th17 cytokines in vitro and in vivo, and reduces clinical severity of autoimmune disease in a mouse multiple scelrosis model [2].