Auphen   Click here for help

GtoPdb Ligand ID: 10188

Compound class: Inorganic
Comment: Auphen is a gold (Au)-containing compound that was designed as a potential anticancer agent [2]. It has been shown to act as an inhibitor of aquaglyceroporins AQP3 and -7 [1].
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
AQP3 Hs Inhibitor - 6.1 pIC50 - 1
pIC50 6.1 (IC50 8x10-7 M) [1]
Description: In human RBCs.
AQP7 Hs Inhibitor - - - -
Effective at 15 μM