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Compound class: Inorganic
Comment: Auphen is a gold (Au)-containing compound that was designed as a potential anticancer agent . It has been shown to act as an inhibitor of aquaglyceroporins AQP3 and -7 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Martins AP, Marrone A, Ciancetta A, Galán Cobo A, Echevarría M, Moura TF, Re N, Casini A, Soveral G. (2012)
Targeting aquaporin function: potent inhibition of aquaglyceroporin-3 by a gold-based compound.
PLoS ONE, 7 (5): e37435. [PMID:22624030]
2. Messori L, Abbate F, Marcon G, Orioli P, Fontani M, Mini E, Mazzei T, Carotti S, O'Connell T, Zanello P. (2000)
Gold(III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold(III) compounds.
J Med Chem, 43 (19): 3541-8. [PMID:11000008]