SAR7334   Click here for help

GtoPdb Ligand ID: 10283

Synonyms: SAR-7334
PDB Ligand
Compound class: Synthetic organic
Comment: SAR7334 blocks calcium entry via TRPC6, TRPC3 and TRPC7 ion channels [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 62.28
Molecular weight 367.15
XLogP 3.6
No. Lipinski's rules broken 0
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Canonical SMILES N#Cc1ccc(c(c1)Cl)OC1C(Cc2c1cccc2)N1CCCC(C1)N
Isomeric SMILES N#Cc1ccc(c(c1)Cl)O[C@H]1[C@@H](Cc2c1cccc2)N1CCC[C@H](C1)N
InChI InChI=1S/C21H22ClN3O/c22-18-10-14(12-23)7-8-20(18)26-21-17-6-2-1-4-15(17)11-19(21)25-9-3-5-16(24)13-25/h1-2,4,6-8,10,16,19,21H,3,5,9,11,13,24H2/t16-,19-,21-/m1/s1
Bioactivity Comments
SAR7334 does not block TRPC4 and TRPC5-mediated Ca2+ entry [1].
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPC6 Hs Channel blocker - 8.0 pIC50 - 1
pIC50 8.0 (IC50 9.5x10-9 M) [1]
TRPC7 Hs Channel blocker - 6.7 pIC50 - 1
pIC50 6.7 (IC50 2.26x10-7 M) [1]
TRPC3 Hs Channel blocker - 6.6 pIC50 - 1
pIC50 6.6 (IC50 2.82x10-7 M) [1]