AC1903   Click here for help

GtoPdb Ligand ID: 10290

Synonyms: AC-1903
Compound class: Synthetic organic
Comment: AC1903 is small-molecule inhibitor of TRPC5 ion channels that has demonstrated in vivo activity [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 42.99
Molecular weight 303.14
XLogP 3.88
No. Lipinski's rules broken 0
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Canonical SMILES c1ccc(cc1)Cn1c(NCc2ccco2)nc2c1cccc2
Isomeric SMILES c1ccc(cc1)Cn1c(NCc2ccco2)nc2c1cccc2
InChI InChI=1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)
Bioactivity Comments
AC1903 is selective for TRPC5 compared to TRPC4 and TRPC6, and exhibited no off-target effects in a kinase profiling screen [1].
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPC5 Hs Channel blocker Inhibition 4.8 pIC50 - 1
pIC50 4.8 (IC50 1.47x10-5 M) [1]
Description: Inhibition of riluzole-activated TRPC5 whole-cell current by patch-clamp recording.