stanozolol   Click here for help

GtoPdb Ligand ID: 10369

Synonyms: Stromba® | Tevabolin® | WIN-14833 | WIN14833 | Winstrol®
Approved drug
stanozolol is an approved drug (FDA (1962))
Compound class: Synthetic organic
Comment: Stanozolol is a synthetic, orally active steroid that has anabolic and androgenic properties [3]. Chemically, it is a 17α-alkylated derivative of dihydrotestosterone. It has low binding affinity for the androgen receptor, but is a strong activator of androgen receptor-induced protein synthesis and erythropoietin production [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 48.91
Molecular weight 328.25
XLogP 5.86
No. Lipinski's rules broken 1
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Canonical SMILES CC12Cc3cn[nH]c3CC1CCC1C2CCC2(C1CCC2(C)O)C
Isomeric SMILES C[C@]12Cc3cn[nH]c3C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(C)O)C
InChI InChI=1S/C21H32N2O/c1-19-11-13-12-22-23-18(13)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,24H,4-11H2,1-3H3,(H,22,23)/t14-,15+,16-,17-,19-,20-,21-/m0/s1
Selectivity at nuclear hormone receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Androgen receptor Rn Agonist Agonist 7.7 pIC50 - 2
pIC50 7.7 (IC50 2.2x10-8 M) [2]
Description: Measured in a DrugMatrix in vitro androgen receptor radioligand binding assay using [3H] mibolerone as tracer.
Estrogen receptor-α Hs Agonist Agonist 6.9 pIC50 - 2
pIC50 6.9 (IC50 1.13x10-7 M) [2]
Description: Measured in a DrugMatrix estrogen receptor α radioligand binding assay using [3H] estradiol as tracer.