Compound class:
Synthetic organic
Comment: SZM594 is a dual RIPK1/RIPK3 inhibitor that blocks necroptosis [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
SZM594 inhibits TSZ‐induced necroptosis in HT‐29 cells with an EC50 of 170 nM [1]. TSZ is a mixture of TNFα, a Smac mimetic, and the caspase inhibitor z‐VAD‐FMK that is used to induce necroptosis. |
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