Synonyms: compound 36 [PMID: 22734674] | TSR-011 | TSR011
Compound class:
Synthetic organic
Comment: Belizatinib (TSR-011) is an inhibitor of anaplastic lymphoma kinase (ALK) [1]. It is reported as being potent, selective, and orally bioavailable, and was designed by Tesaro for potential anti-tumour activity.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Belizatinib (TSR-011) inhibits ALK Tyr1604 phosphorylation in intact cells with an IC50 of 4 nM [1]. |
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Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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