Ligand id: 10665

Name: UCSF3384

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 53.6
Molecular weight 292.17
XLogP 5.76
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
When administered at dusk, UCSF3384 advanced the phase of the circadian clock, in a MT1 receptor-dependent manner, in mice [1].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
MT1 receptor Hs Agonist Inverse agonist 7.9 pEC50 - 1
pEC50 7.9 (EC50 1.259x10-8 M) [1]
MT2 receptor Hs Agonist Inverse agonist 6.2 pEC50 - 1
pEC50 6.2 (EC50 6.31x10-7 M) [1]