ambroxol

Ligand id: 10692

Name: ambroxol

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 58.28
Molecular weight 375.98
XLogP 2.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
Ambroxol behaves as an inhibitory GCase chaperone at neutral pH, so within acellular human CSF it produces an inhibitory effect on GCase activity [11]. In contrast, within cells and their acidic lysosomes ambroxol increases intracellular GCase activity by elevating the enzyme mass that reaches the lysosomes [8-9].
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
glucosylceramidase beta Hs None Binding - - - 5
[5]