Synonyms: Hiprex® | Mandelamine® | Urex®
methenamine is an approved drug (FDA (1967), UK (1989))
Compound class:
Synthetic organic
Comment: Methenamine is a heterocyclic organic compound. It is metabolised to formaldehyde, which acts as a nonspecific bactericidal agent. Methenamine is administered as the hippuric acid salt, methenamine hippurate (PubChem CID 21945).
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Bioactivity Comments |
We have been unable to find quantitative data for the antibacterial activity of this drug. At mammalian targets, 10 μM methenamine hippurate inhibits sodium fluorescein uptake via hamster OATP1B1 in transfected CHO cells by 93% [1]. |