Compound class:
Synthetic organic
Comment: RP60556A is the most potent compound from the benzo[b]naphthyridones, a series of antibacterial compounds active against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) [1]. It was being developed as a topical treatment by Sanofi-Aventis but has been discontinued.
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Bioactivity Comments |
MIC for antibacterial activity is 0.5μg/ml against Staphylococcus aureus LF11C128B (quinolone resistant) and 0.25μg/ml against Staphylococcus hominis IP8203 (quinolone sensitive) [1]. |