Compound class:
Natural product or derivative
Comment: Napsamycin C and napsamycin D are uridylpeptide antibacterials, sharing a common structural scaffold with the mureidomycins and pacidamycins. Originally isolated from Streptomyces sp. HIL Y-82,11372, napsamycins have potent activity against Pseudomonas species but not against other Gram-negative or Gram-positive bacteria [1].
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Bioactivity Comments |
Napsamycin C activity is specifically against Pseudomonas strains. The MIC for antimicrobial activity is 12.5 μg/ml for Pseudomonas aeruginosa M35 and 100 μg/ml for Pseudomonas fluorescens [1]. The same study reported that napsamycin C exhibits very poor activity against other Gram-negative and Gram-positive bacteria. |