Compound class:
Natural product or derivative
Comment: Napsamycin C and napsamycin D are uridylpeptide antibacterials, sharing a common structural scaffold with the mureidomycins and pacidamycins. Originally isolated from Streptomyces sp. HIL Y-82,11372, napsamycins have potent activity against Pseudomonas species but not against other Gram-negative or Gram-positive bacteria [1].
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References |
1. Chatterjee S, Nadkarni SR, Vijayakumar EK, Patel MV, Ganguli BN, Fehlhaber HW, Vertesy L. (1994)
Napsamycins, new Pseudomonas active antibiotics of the mureidomycin family from Streptomyces sp. HIL Y-82,11372. J Antibiot, 47 (5): 595-8. [PMID:8040059] |
2. Murakami R, Fujita Y, Kizuka M, Kagawa T, Muramatsu Y, Miyakoshi S, Takatsu T, Inukai M. (2008)
A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity. J Antibiot, 61 (9): 537-44. [PMID:19160520] |