cannabidivarin   Click here for help

GtoPdb Ligand ID: 11092

Synonyms: CBDV | GWP42006
Comment: Cannabidivarin is a non-psychoactive phytocannabinoid found in plants of the Cannabis species.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 40.46
Molecular weight 286.19
XLogP 5.67
No. Lipinski's rules broken 1
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Canonical SMILES CCCc1cc(O)c(c(c1)O)[C@H]1C=C(C)CC[C@@H]1C(=C)C
Isomeric SMILES CCCc1cc(O)c(c(c1)O)[C@H]1C=C(C)CC[C@@H]1C(=C)C
InChI InChI=1S/C19H26O2/c1-5-6-14-10-17(20)19(18(21)11-14)16-9-13(4)7-8-15(16)12(2)3/h9-11,15-16,20-21H,2,5-8H2,1,3-4H3/t15-,16+/m1/s1
Bioactivity Comments
The anti-epileptic activity (reduction of neuronal hyperexcitability that plays a role in epileptic activity and seizures) of CBDV is thought to be mediated by its effect on transient receptor potential (TRP) cation channels, such as TRAP subfamily V member 1 (TRPV1, a.k.a. capsaicin receptor), TRPV2 and TRPA1. CBDV reduces seizures in pre-clinical models of epilepsy.