cannabidivarin   Click here for help

GtoPdb Ligand ID: 11092

Synonyms: CBDV | GWP42006
Comment: Cannabidivarin is a non-psychoactive phytocannabinoid found in plants of the Cannabis species.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 40.46
Molecular weight 286.19
XLogP 5.67
No. Lipinski's rules broken 1
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Canonical SMILES CCCc1cc(O)c(c(c1)O)[C@H]1C=C(C)CC[C@@H]1C(=C)C
Isomeric SMILES CCCc1cc(O)c(c(c1)O)[C@H]1C=C(C)CC[C@@H]1C(=C)C
InChI InChI=1S/C19H26O2/c1-5-6-14-10-17(20)19(18(21)11-14)16-9-13(4)7-8-15(16)12(2)3/h9-11,15-16,20-21H,2,5-8H2,1,3-4H3/t15-,16+/m1/s1
No information available.
Summary of Clinical Use Click here for help
Cannabidivarin (CBDV) is being investigated for clinical anticonvulsant (anti-epileptic) activity. It is also being evaluated for therapeutic benefit on communication, social interactions, sleep, behaviour, and cognition in people with autism spectrum disorder. In the EU CBDV has orphan designations for the treatment of Rett syndrome (2017) and fragile X syndrome (2018).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03849456 Safety and Tolerability of Cannabidivarin (CBDV) in Children and Young Adults With Autism Spectrum Disorder Phase 2 Interventional GW Research Ltd
NCT02369471 A Study of GWP42006 in People With Focal Seizures - Part A Phase 2 Interventional GW Research Ltd
NCT02365610 A Study of GWP42006 in People With Focal Seizures - Part B Phase 2 Interventional GW Research Ltd