DPO-1   Click here for help

GtoPdb Ligand ID: 11207

Synonyms: diphenyl phosphine oxide-1 | DPO1
Compound class: Synthetic organic
Comment: DPO-1 is a Kv1.5 channel blocker [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 26.88
Molecular weight 340.2
XLogP 7.13
No. Lipinski's rules broken 1
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Canonical SMILES C[C@@H]1CC[C@H]([C@H](C1)P(=O)(c1ccccc1)c1ccccc1)C(C)C
Isomeric SMILES C[C@@H]1CC[C@H]([C@H](C1)P(=O)(c1ccccc1)c1ccccc1)C(C)C
InChI InChI=1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kv1.5 Hs Channel blocker - 7.3 pIC50 - 1
pIC50 7.3 (IC50 5x10-8 M) [1]
Description: Inhibition of human Kv1.5 channel expressed in CHO cells by whole cell patch clamp assay.