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Synonyms: 18β-Glycyrrhetinic acid | glycyrrhetic acid | glycyrrhetinic acid
Compound class:
Synthetic organic
Comment: Enoxolone is a bioactive metabolite of glycyrrhizin, which is a compound found in the liquorice plant Glycyrrhiza glabra. It has been found to inhibit enzymes that metabolise the prostaglandins PGE2 and PGF2α to their inactive metabolites, and 11β-hydroxysteroid dehydrogenases (HSD11B1, HSD11B2) which convert active cortisol to inactive cortisone. Enoxolone has proposed anti-inflammatory [4-5,8,10] and antitussive effects as well as action against pathogens (viruses, fungal infections, bacterial infections) [1,3,7], and beneficial actions for the treatmant of gastric ulcers.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Enoxolone displays antibacterial activity at high concentration in vitro (7.82 to 125 μg/ml) and been found to reduce virulence of methicillin-resistant Staphylococcus aureus (MRSA) in a murine skin infection model [7]. |
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