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Synonyms: M70 | NGM-282 | NGM282
Compound class:
Peptide or derivative
Comment: Aldafermin (NGM282) is a recombinant, engineered analogue of FGF-19 (FGF19-mimetic) that was developed by NGM Biopharmaceuticals. Acting via the FGFR4-β-Klotho (KLB) receptor complex, aldafermin acts to suppress cholesterol 7α-hydroxylase (CYP7A1), the first and rate-limiting enzyme for bile acids biosynthesis.
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| Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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