feladilimab   Click here for help

GtoPdb Ligand ID: 11649

Synonyms: GSK-3359609
Compound class: Antibody
Comment: Feladilimab (GSK3359609) is a humanized IgG4 anti-ICOS monoclonal antibody that was developed for immuno-oncology potential. It was withdrawn from development in mid-2021 following a failure to demonstrate efficacy in a Phase 2 trial in patients with non-small cell lung cancer.
Peptide sequence analysis suggests that feladilimab is derived from clone H2L5 hIgG4PE in GSK patent WO2016120789 [1]. Feladilimab competes with ICOS ligand for binding to ICOS.
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Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
ICOS (CD278) Monkey Antibody Binding 9.0 pKd - 1
pKd 9.0 (Kd 9.5x10-10 M) [1]
ICOS (CD278) Hs Antibody Binding 8.9 pKd - 1
pKd 8.9 (Kd 1.34x10-9 M) [1]