feladilimab   Click here for help

GtoPdb Ligand ID: 11649

Synonyms: GSK-3359609
Compound class: Antibody
Comment: Feladilimab (GSK3359609) is a humanized IgG4 anti-ICOS monoclonal antibody that was developed for immuno-oncology potential. It was withdrawn from development in mid-2021 following a failure to demonstrate efficacy in a Phase 2 trial in patients with non-small cell lung cancer.
Peptide sequence analysis suggests that feladilimab is derived from clone H2L5 hIgG4PE in GSK patent WO2016120789 [1]. Feladilimab competes with ICOS ligand for binding to ICOS.
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1. Liu Y-b, Parmar RS, Mayes P, Olive D. (2016)
Agonistic icos binding proteins.
Patent number: WO2016120789A1. Assignee: Glaxosmithkline Intellectual Property Development Limited, Inserm (Institut National De La Sante Et De La Recherche Medicale), Institut Jean Paoli & Irene Calmettes, Universite D'aix-Marseille, Centre National De La Recherche Scientifique. Priority date: 28/01/2015. Publication date: 04/08/2016.