Synonyms: ASTX-029 | ASTX029 | compound 15 [PMID: 34387469]
Compound class:
Synthetic organic
Comment: ASTX029 is an orally bioavailable, clinical stage inhibitor of ERK1/2 kinases [1]. It was designed to inhibit the mitogen-activated protein kinase pathway in cancer cells. ASTX029 suppresses both ERK phosphorylation and enzymatic activity [2]. This was matched to the INN beroterkib (Proposed list 131, August 2024).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Selectivity at enzymes | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|