anumigilimab   Click here for help

GtoPdb Ligand ID: 11761

Synonyms: CSL-324 | CSL324
Compound class: Antibody
Comment: Anumigilimab (CSL-324) is a clinical stage monoclonal antibody that targets colony stimulating factor 3 receptor (CSF3R). It was developed by CSL Behring for potential efficacy in inflammatory/autoimmune diseases. The heavy and light chain peptide sequences for anumigilimab are claimed in patent WO2012171057A1 [1].
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Granulocyte colony-stimulating factor receptor Monkey Antibody Binding 9.3 pKd - 1
pKd 9.3 (Kd 4.9x10-10 M) [1]
Description: Binding of immobilised antibody to cynomolgus monkey CSF3R
Granulocyte colony-stimulating factor receptor Primary target of this compound Hs Antibody Binding 8.9 pKd - 1
pKd 8.9 (Kd 1.4x10-9 M) [1]
Description: Binding of immobilised antibody to hCSF3R