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Synonyms: IBX | OPP-3
Compound class: Synthetic organic
Comment: Iboxamycin (OPP-3) is an orally bioavailable, synthetic antibacterial compound . Structurally, IBX is built on a oxepanoproline scaffold that is linked to the aminooctose residue of clindamycin. X-ray crystallography shows that IBX binds to the large ribosomal subunit in the bacteria (more effectively than clindamycin) and disrupts translation initiation. Iboxamycin is a novel broad-spectrum agent that is active against Gram-positive and Gram-negative bacteria including ESKAPE pathogens that express resistance-conferring Erm and Cfr ribosomal RNA methyltransferase enzymes.
|Iboxamycin (OPP-3) is active against a wide range of antibacterial resistant bacterial strains, including multidrug-resistant strains of S. aureus, E. faecalis, E. coli, K. pneumoniae and A. baumannii . For example, IBX's MIC50 against a strain of E. coli that's resistant to cephalosporin, fluoroquinolone, tetracycline and aminoglycoside antibacterials is 8 μg/ml.|