Synonyms: IBX | OPP-3
Compound class:
Synthetic organic
Comment: Iboxamycin (OPP-3) is an orally bioavailable, synthetic antibacterial compound [1]. Structurally, IBX is built on a oxepanoproline scaffold that is linked to the aminooctose residue of clindamycin. X-ray crystallography shows that IBX binds to the large ribosomal subunit in the bacteria (more effectively than clindamycin) and disrupts translation initiation. Iboxamycin is a novel broad-spectrum agent that is active against Gram-positive and Gram-negative bacteria including ESKAPE pathogens that express resistance-conferring Erm and Cfr ribosomal RNA methyltransferase enzymes.
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References |
1. Mitcheltree MJ, Pisipati A, Syroegin EA, Silvestre KJ, Klepacki D, Mason JD, Terwilliger DW, Testolin G, Pote AR, Wu KJY et al.. (2021)
A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature, 599 (7885): 507-512. [PMID:34707295] |