Synonyms: compound B [WO2022002018A1] | LY-3499446
Compound class:
Synthetic organic
Comment: LY3499446 is a direct inhibitor of oncogenic KRAS mutant G12C that was developed for anticancer potential [1].
|
|
Bioactivity Comments |
LY3499446 inhibits downstream KRASG12C-mediated ERK phosphorylation in NCI-H358 cells with an IC50 of 8.9 nM [2]. |
Selectivity at enzymes | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
|