Compound class:
Synthetic organic
Comment: C004019 is a small-molecule PROTAC that selectively promotes tau protein degradation [1]. It was designed to reduce tau burden as a mechanism to improve cognitive functions in Alzheimer's disease and other tauopathies. C004019 binds simultaneously to tau and to the VHL E3-ligase to promote selective proteasomal degradation of tau.
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Bioactivity Comments |
C004019 selectively and efficiently promotes tau clearance in preclinical models [1]. We have been unable to find quantitative data for the interactions between C004019 and either VHL or tau. Evidence of tau reduction in vitro and improved cognitive and synaptic functions following C004019 adminsitration in vivo, are reported in [1]. |