Compound class:
Synthetic organic
Comment: C004019 is a small-molecule PROTAC that selectively promotes tau protein degradation [1]. It was designed to reduce tau burden as a mechanism to improve cognitive functions in Alzheimer's disease and other tauopathies. C004019 binds simultaneously to tau and to the VHL E3-ligase to promote selective proteasomal degradation of tau.
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References |
1. Wang W, Zhou Q, Jiang T, Li S, Ye J, Zheng J, Wang X, Liu Y, Deng M, Ke D et al.. (2021)
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics, 11 (11): 5279-5295. [PMID:33859747] |