Synonyms: BAY 1165747 [2] | BAY747 | compound 28 [PMID: 37040336]
Compound class:
Synthetic organic
Comment: BAY-747 is an orally active and brain-penetrant soluble guanylyl cyclase (sGC) stimulator [2-3]. It was developed to treat resistant hypertension. It has also been suggested as a potential therapy for Duchenne muscular dystrophy, that is proposed to improve skeletal muscle function via activation of the NO-sGC-cGMP pathway [1]
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Bioactivity Comments |
The MEC (minimal effective concentration to stimulate cGMP formation by ≥3-fold above baseline) for BAY-747 in a recombinant sGC-overexpressing cell line is 60 nM [2]. |