Synonyms: BAY 1165747 [2] | BAY747 | compound 28 [PMID: 37040336]
Compound class:
Synthetic organic
Comment: BAY-747 is an orally active and brain-penetrant soluble guanylyl cyclase (sGC) stimulator [2-3]. It was developed to treat resistant hypertension. It has also been suggested as a potential therapy for Duchenne muscular dystrophy, that is proposed to improve skeletal muscle function via activation of the NO-sGC-cGMP pathway [1]
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References |
1. Krishnan SM, Nordlohne J, Dietz L, Vakalopoulos A, Haning P, Hartmann E, Seifert R, Hüser J, Mathar I, Sandner P. (2021)
Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy. Int J Mol Sci, 22 (15). DOI: 10.3390/ijms22158016 [PMID:34360780] |
2. Vakalopoulos A, Wunder F, Hartung IV, Redlich G, Jautelat R, Buchgraber P, Hassfeld J, Gromov AV, Lindner N, Bierer D et al.. (2023)
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension. J Med Chem, 66 (11): 7280-7303. [PMID:37040336] |
3. Wunder F, Stasch JP, Knorr A, Mondritzki T, Brockschnieder D, Becker-Pelster EM, Sandner P, Tinel H, Redlich G, Hartung IV et al.. (2023)
Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension. Br J Pharmacol, 180 (19): 2500-2513. [PMID:37170767] |