Synonyms: MD224
Compound class:
Synthetic organic
Comment: MD-224 is a PROTAC class degrader molecule of the MDM2 proto-oncogene (an E3 ubiquitin-protein ligase that acts as a negative regulator of the p53 tumour suppressor). PROTACs that recruit MDM2 simultaneously antagonise interaction with p53, promote MDM2 degradation and increase intracellular p53 [1-2]. MD-224 was designed to demonstrate the anti-tumour effect of this strategy.
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Bioactivity Comments |
Inhibits proliferation of MV4-11 and RS4;11 lymphoblast cells in vitro [3]. |