MD-224   Click here for help

GtoPdb Ligand ID: 12914

Synonyms: MD224
Compound class: Synthetic organic
Comment: MD-224 is a PROTAC class degrader molecule of the MDM2 proto-oncogene (an E3 ubiquitin-protein ligase that acts as a negative regulator of the p53 tumour suppressor). PROTACs that recruit MDM2 simultaneously antagonise interaction with p53, promote MDM2 degradation and increase intracellular p53 [1-2]. MD-224 was designed to demonstrate the anti-tumour effect of this strategy.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 12
Hydrogen bond donors 5
Rotatable bonds 10
Topological polar surface area 165.81
Molecular weight 889.8
XLogP 2.45
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C(C#CC1=CC=CC2=C1CN(C3CCC(=O)NC3=O)C2=O)CCNC(=O)C4=CC=C(C=C4)NC(=O)[C@H]5[C@H](C6=CC=CC(=C6F)Cl)[C@@]7(C8=CC=C(C=C8NC7=O)Cl)C9(CCCCC9)N5
Isomeric SMILES C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NC4=CC=C(C=C4)C(=O)NCCCC#CC5=C6CN(C(=O)C6=CC=C5)C7CCC(=O)NC7=O)C8=C(C(=CC=C8)Cl)F)C9=C(C=C(C=C9)Cl)NC3=O
InChI InChI=1S/C48H43Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-2,4-6,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1
InChI Key ZLGNYFOIDAVMHY-MPKOGUQCSA-N
References
1. Fang Y, Liao G, Yu B. (2020)
Small-molecule MDM2/X inhibitors and PROTAC degraders for cancer therapy: advances and perspectives.
Acta Pharm Sin B, 10 (7): 1253-1278. [PMID:32874827]
2. Vicente ATS, Salvador JAR. (2022)
MDM2-Based Proteolysis-Targeting Chimeras (PROTACs): An Innovative Drug Strategy for Cancer Treatment.
Int J Mol Sci, 23 (19). [PMID:36232374]
3. Wang S, Li Y, Yang J, Aguilar A, Zhou B, Hu J, Xu F, Rej R, Han X. (2017)
Mdm2 protein degraders.
Patent number: WO2017176957A1. Assignee: The Regents Of The University Of Michigan. Priority date: 06/04/2017. Publication date: 12/10/2017.