Synonyms: ARX-1796 | AV-006 | PF-07338233
Compound class:
Synthetic organic
Comment: Avibactam tomilopil is an orally available prodrug of the β-lactamase inhibitor avibactam [1]. Pfizer are developing an oral combined formulation of avibactam tomilopil and ceftibuten for the treatment of complicated urinary tract infections (cUTIs) [2].
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Bioactivity Comments |
Adding orally active avibactam tomilopil to ceftibuten expands its Gram-negative antibacterial spectrum to include more recent Extended Spectrum Beta-Lactamase (ESBL)-producing (CTX-M) and carbapenemase-producing (KPC and OXA-48) Enterobacterales isolates [2]. |