Synonyms: HER096
Compound class:
Peptide or derivative
Comment: HER-096 (Herantis Pharma) is a metabolically stable cerebral dopamine neurotrophic factor (CDNF) peptidomimetic that can cross the blood-brain barrier [2]. Its sequence is derived from the C-terminal domain of CDNF. HER-096 was designed to overcome the limitations associated with administration of a therapeutic formulation of native CDNF directly into the human brain. CDNF (and CDNF mimetics) has been identified as a novel neuroprotective disease-modifying therapy for Parkinson's disease [1-2].
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Bioactivity Comments |
HER-096 is active in vivo, protecting dopaminergic neurons in a mouse synucleinopathy model of Parkinson's disease [2]. |