Synonyms: HER096
Compound class:
Peptide or derivative
Comment: HER-096 (Herantis Pharma) is a metabolically stable cerebral dopamine neurotrophic factor (CDNF) peptidomimetic that can cross the blood-brain barrier [2]. Its sequence is derived from the C-terminal domain of CDNF. HER-096 was designed to overcome the limitations associated with administration of a therapeutic formulation of native CDNF directly into the human brain. CDNF (and CDNF mimetics) has been identified as a novel neuroprotective disease-modifying therapy for Parkinson's disease [1-2].
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References |
1. Huttunen HJ, Booms S, Sjögren M, Kerstens V, Johansson J, Holmnäs R, Koskinen J, Kulesskaya N, Fazio P, Woolley M et al.. (2023)
Intraputamenal Cerebral Dopamine Neurotrophic Factor in Parkinson's Disease: A Randomized, Double-Blind, Multicenter Phase 1 Trial. Mov Disord, 38 (7): 1209-1222. [PMID:37212361] |
2. Kulesskaya N, Bhattacharjee A, Holmström KM, Vuorio P, Henriques A, Callizot N, Huttunen HJ. (2024)
HER-096 is a CDNF-derived brain-penetrating peptidomimetic that protects dopaminergic neurons in a mouse synucleinopathy model of Parkinson's disease. Cell Chem Biol, 31 (3): 593-606.e9. [PMID:38039968] |