Synonyms: XNW4107
Compound class:
Synthetic organic
Comment: Funobactam (XNW4107) is a novel serine β-lactamase inhibitor, belonging to the diazabicyclooctane (DBO) class [1]. It enhances the activity of carbapenem antibacterials against carbapenem-resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae [1]. Funobactam is in clinical development in combination with imipenem + cilastatin for the treatment of complicated urinary tract infections (cUTIs) and hospital acquired/ventilator-associated bacterial pneumonia (HABP/VABP).
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Bioactivity Comments |
Funobactam has no intrinsic antibacterial activity but exhibits in vitro activity against Ambler class A, C, and D β-lactamases, including those produced by Acinetobacter baumannii [1]. The combination of funobactamIn with imipenem was found to have potent in vitro activity against carbapenem-resistant Gram-negative bacteria [1]. |