Synonyms: XNW4107
Compound class:
Synthetic organic
Comment: Funobactam (XNW4107) is a novel serine β-lactamase inhibitor, belonging to the diazabicyclooctane (DBO) class [1]. It enhances the activity of carbapenem antibacterials against carbapenem-resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae [1]. Funobactam is in clinical development in combination with imipenem + cilastatin for the treatment of complicated urinary tract infections (cUTIs) and hospital acquired/ventilator-associated bacterial pneumonia (HABP/VABP).
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References |
1. Li Y, Yan M, Xue F, Zhong W, Liu X, Chen X, Wu Y, Zhang J, Wang Q, Zheng B et al.. (2022)
In vitro and in vivo activities of a novel β-lactamase inhibitor combination imipenem/XNW4107 against recent clinical Gram-negative bacilli from China. J Glob Antimicrob Resist, 31: 1-9. [PMID:35820591] |