Synonyms: compound 46 [PMID: 30803745]
Compound class:
Synthetic organic
Comment: TBAJ-876, an analogue of bedaquiline, was discovered at the University of Auckland following a lead optimization project to identify novel members of the diarylquinolines class of antibacterial compounds [3]. TBAJ-876 has a more favourable ADME profile, lower risk of QT prolongation, and more potent antimycobacterial activity than bedaquiline [3].
See also our entry for TBAJ-587 that was identified in the same study. |
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