Synonyms: Phenylbenzothiazole-PEG4-OH | SPG-302
Compound class:
Synthetic organic
Comment: SPG302 induces synaptogenic regenerative actions in neural tissues [1-2]. Mechanistically SPG302 targets a regulator of the F-actin-based cytoskeleton to increase dendritic spine density and promote the formation of new synapses. It increases the density of axospinous glutamatergic synapses in Alzheimer's disease model mice.
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Bioactivity Comments |
SPG302 reverses synaptic and cognitive deficits in a mouse Alzheimer's disease model without altering amyloid β- or phosphoTau-associated pathologies [2]. |