Synonyms: Phenylbenzothiazole-PEG4-OH | SPG-302
Compound class:
Synthetic organic
Comment: SPG302 induces synaptogenic regenerative actions in neural tissues [1-2]. Mechanistically SPG302 targets a regulator of the F-actin-based cytoskeleton to increase dendritic spine density and promote the formation of new synapses. It increases the density of axospinous glutamatergic synapses in Alzheimer's disease model mice.
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References |
1. Fogarty MJ, Zhan WZ, Simmon VF, Vanderklish PW, Sarraf ST, Sieck GC. (2023)
Novel regenerative drug, SPG302 promotes functional recovery of diaphragm muscle activity after cervical spinal cord injury. J Physiol, 601 (12): 2513-2532. [PMID:36815402] |
2. Trujillo-Estrada L, Vanderklish PW, Nguyen MMT, Kuang RR, Nguyen C, Huynh E, da Cunha C, Javonillo DI, Forner S, Martini AC et al.. (2021)
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease. Neurotherapeutics, 18 (4): 2468-2483. [PMID:34738197] |