3,5-DHPG   Click here for help

GtoPdb Ligand ID: 1367

Synonyms: 3,5-dihydroxyphenylglycine
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 103.78
Molecular weight 183.05
XLogP -2.59
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)C(c1cc(O)cc(c1)O)N
Isomeric SMILES OC(=O)C(c1cc(O)cc(c1)O)N
InChI InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
mGlu1 receptor Rn Agonist Full agonist 5.8 pKi - 1
pKi 5.8 [1]
mGlu5 receptor Rn Agonist Partial agonist 5.4 pIC50 - 2
pIC50 5.4 [2]
Ligand mentioned in the following text fields