Lysergide

Ligand id: 17

Name: Lysergide

Abbreviated name: LSD

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 39.34
Molecular weight 323.2
XLogP 2.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
5-HT2A receptor Hs Agonist Full agonist 9.4 pKi - 1
pKi 9.4 [1]
5-HT1A receptor Hs Agonist Full agonist 9.0 pKi - 5
pKi 9.0 [5]
5-HT2A receptor Rn Agonist Full agonist 8.5 pKi - 5
pKi 8.5 [5]
5-HT2B receptor Hs Agonist Biased agonist 8.4 pKi - 6
pKi 8.4 [6]
Description: Biased for β-arrestin sihnalling.
5-HT2C receptor Hs Agonist Full agonist 8.2 – 8.6 pKi - 4
pKi 8.2 – 8.6 [4]
5-HT6 receptor Hs Agonist Full agonist 8.4 pKi - 3
pKi 8.4 [3]
5-HT2B receptor Rn Agonist Full agonist 8.3 pKi - 5
pKi 8.3 [5]
5-HT6 receptor Rn Agonist Full agonist 7.8 – 8.7 pKi - 2-3
pKi 7.8 – 8.7 [2-3]