GR 63799

Ligand id: 1937

Name: GR 63799

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 131.39
Molecular weight 587.25
XLogP 4.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
EP3 receptor Mm Agonist Partial agonist 8.7 pKi - 3
pKi 8.7 (Ki 1.9x10-9 M) [3]
EP3 receptor Hs Agonist Agonist 8.3 pKi - 1
pKi 8.3 (Ki 4.8x10-9 M) EP3-III isoform [1]
EP3 receptor Rn Agonist Agonist 7.1 pKi - 2
pKi 7.1 (Ki 7.3x10-8 M) EP3α isoform [2]