GW 627368

Ligand id: 1953

Name: GW 627368

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 110.39
Molecular weight 544.17
XLogP 5.03
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
EP4 receptor Hs Antagonist Antagonist 7.0 – 7.1 pKi - 1-2
pKi 7.0 – 7.1 (Ki 1x10-7 – 7.94x10-8 M) [1-2]